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Partners in the consortium are UZ Leuven, KU Leuven, UCB Pharma and Byteflies. The laboratory of epilepsy surgery is based at UZ Leuven, which is a reference center for refractory epilepsy and epilepsy surgery in Belgium. Engineers of KU Leuven are responsible for the development of new algorithms for the automatic detection of epileptic seizures. UCB Pharma is a leading Belgian pharmaceutical company with a special interest in epilepsy (https://www.ucb.com). Byteflies is a Belgian-American wearable health company (https://www.byteflies.com). Our device is based on Byteflies’s “Sensor Dot technology”, and will be further validated with funding from the European Institute of Innovation and Technology (EIT)-Health in the current project. Participating epilepsy centers are Aachen University Hospital, Karolinska Institute, King’s College, Oxford University Hospital, University Hospital Coimbra and University Hospital Freiburg. IESE Business School and Epione BVBA are also partners of the consortium.
This project aims to evaluate clinical scenarios in long-term monitoring of epileptic seizures with a newly developed, unobtrusive wearable device (SeizeIT2). Our device is able to record EEG, heart rate and motion simultaneously. We plan to include more than 500 patients with epilepsy in a European study with seven epilepsy centers. We will focus on three epileptic seizure types: absences, focal impaired awareness seizures and tonic-clonic seizures. In a first hospital-based study, we will register epileptic seizures with gold-standard videoEEG and SeizeIT2. In addition, patients will keep a seizure diary.  The primary objective is the accuracy of seizure detection of the SeizeIT device as compared with that of the gold-standard videoEEG registration, and with the seizure diary of the patient.  In a second home-based study, we will invite patients, who had seizures in the hospital-based study, to wear the SeizeIT device for a week at home, and to keep a seizure diary. The primary objective of the home-based study is the accuracy of seizure detection of the SeizeIT device as compared with the seizure diary of the patient. Secondary objectives are to determine usability of the device, duration and severity of seizures, and changes in medical management due to the device. There will be the possibility that the doctoral student further develops a project using SeizeIT according to his/her interests, e.g. SUDEP, interaction epilepsy-sleep, cyclic rhythms in epilepsy, testing of other biosignals in epilepsy (respiration, oxygen saturation, temperature).
  • You have one of the following qualifications: master in biomedical sciences, master in medicine, neurologist (-in-training)
  • You have an interest in epilepsy and EEG.
  • You have good social skills.
  • You can write and speak English fluently. Knowledge of other languages will be an advantage.
  • You are an excellent organizer.
  • You are a good manager.
  • You are a team player and can work together easily with clinicians, nurses and other health care workers, engineers, pharmacists, economists and the different partners of the consortium.
  • You are eager and capable to publish the results of the studies in peer-reviewed medical journals.
  • You will be appointed for a period of four years. Start date summer 2020 till summer 2024 (we will agree on the exact date). Your work will be based primarily at UZ Leuven.
  • Your aim is to obtain a doctoral thesis (PhD).
  • You are responsible for the clinical validation of the wearable device to detect epileptic seizures. This involves supervision and coordination of the multicentric data collection, which will start Q2-Q3 2020 for a period of 1.5 years.
  • You are expected to liaise with the different European partners, keep close contact and visit the centers.
  • A clinical trial assistant/clinical support manager will support your work.
  • Product validation, which is your responsibility, runs in parallel with product design, algorithm design to detect seizures automatically, product development and business development. It will be crucial for the project that you cooperate closely with the other partners responsible for these parallel tracts.
For more information please contact Prof. dr. Wim Van Paesschen, tel.: +3216344332, mail: wim.vanpaesschen@kuleuven.be.
You can apply for this job no later than August 21, 2020 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.

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