PhD-position in Biochemistry – Autophagy mechanisms 12 views

  •  Temporary position longer than 6 months
  •  100%
  •  Umeå

At the Department of Chemistry we are looking for a doctoral candidate within the project autophagy mechanisms. Last day to apply is 29 April 2020.

The lab is located within the cross-disciplinary Chemical Biological Centre (video) (https://www.umu.se/en/chemical-biological-centre/) at Umeå University and provides excellent facilities and state-of-art equipment and platforms in a creative, inspiring, international and highly interactive environment. Facilities include Protein Expertise Platform, X-ray, Proteomics, NMR (850-400 MHz), Cryo-EM and Biochemical Imaging Centre (confocal, FLIM, spinning disk, TIRF, STORM). The recent breakthrough researches from Umeå University include deciphering the molecular mechanisms of the bacterial CRISPR-Cas9 system and repurposing it into a tool for genome editing.

Project description
Autophagy is an evolutionarily conserved self-eating process mainly to eliminate or recycle dysfunctional cellular organelles or unused proteins. Autophagy plays an important role in physiology including development and ageing and has been associated with diverse human diseases, including cancer, neurodegeneration, cardiac hypertrophy, and pathogen infection. Autophagy modulation is implicated in the treatment of diseases such as neurodegeneration and cancer. Despite extensive work, the models of autophagosome formation and autophagy regulation are not yet well established. Our laboratory has elucidated fundamental mechanisms underlying autophagosome formation and new mechanisms of autophagy regulation (eLife 2017, Angew Chem 2017, Nat Chem Biol 2019). We will combine cell biological, biochemical, and novel chemical and chemo-optogenetic approaches to understand the mechanism of autophagic membrane morphogenesis and bacterial interaction with host autophagy. The PhD student will focus on cell imaging, western blotting, knock-out/down, analysis of cellular phenotypes, protein expression and purification, biochemical and structural characterization. The project is funded by European Research Council (ERC) and Wallenberg Foundation. The project is interdisciplinary with strong collaborations across scientific disciplines.

Qualifications
To be admitted for studies at third-cycle level you are required to have completed a second-cycle level degree, or completed course requirements of at least 240 ECTS credits, of which at least 60 ECTS credits are at second-cycle level or have an equivalent education from abroad, or equivalent qualifications.

To fulfil the specific entry requirements to be admitted for studies at third-cycle level in chemistry, you are required to have completed first-cycle courses of at least 90 ECTS credits within the field of chemistry or another subject considered to be directly relevant to the specialization in question. Of those 90 ECTS credits, at least 15 ECTS credits shall have been acquired at second-cycle level within the specialization or an equivalent subject.

Very good language skills in English, both spoken and written, is required. Experiences in cell imaging, western blotting, molecular cloning, siRNA, CRISPR-Cas, and/or protein expression and protein purification are strong merits.

Terms of employment
The appointment aims at a PhD degree and the main task of the PhD student is to pursue their doctoral studies, which includes participation in research projects as well as postgraduate courses. In the assignments, teaching and other departmental work (up to a maximum of 20%) can be included. The employment is limited to four years full-time or up to five years when part-time teaching. The salary placement takes place according to the established salary level for doctoral employment.

Application
A complete application should contain the following documents:

  • A cover letter including a description of your qualifications, research interests and motivation for applying (max 2 pages)
  • A Curriculum Vitae
  • Copies of degree certificates or equivalent, including documentation of completed academic courses and obtained grades
  • Name and contact information of at least two reference persons

Applications must be submitted via our e-recruitment system. The last day to apply is 29 April 2020. For further information you are welcome to contact Professor Yaowen Wu, E-mail: yaowen.wu@umu.sehttps://www.umu.se/en/staff/yaowen-wu/. Website: https://www.biostruct.umu.se/principal-investigators/yaowen-wu/

About us
The Department of Chemistry is one of the largest departments within the Faculty of Science and Technology with approximately 200 employees, of which approximately 40 PhD students, and a strong and expanding research. The Department has three major research areas: Biological Chemistry, Environmental and Biogeochemistry, and Technical Chemistry, see: https://www.umu.se/en/department-of-chemistry/. Information about doctoral studies in chemistry, see: https://www.umu.se/en/faculty-of-science-and-technology/education/doctoral-studies/chemistry/. For more information about working at Umeå University, see: https://www.umu.se/en/work-with-us/.

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